pound of Claim 5 wherein R 2 is phenyl ^, wherein said phenyl group is substituted with heteroaryl, which is optionally substituted with OR 9 or R 9, or a pharmaceutically acceptable salt thereof.ħ. Or a pharmaceutically acceptable salt thereof.Ħ. 20 mM NaHCO3, 0.5 mM EDTA, 50 mM ME, 0.5 g casein, 1 g poly-vinyl. (4) heterocyclyl, (5) heteroaryl, which is optionally substituted with one to two suhstituents independently selected from the group consisting of (CO)OR 9, NR 5R 9, NH(C=0)OR 9, NH(C=0)R 9 (C=0)NHR 9, OR 9 and R 9, The compound of Claim 1 wherein R is phenyl, wherein said phenyl group is optionally substituted with one to two substituents independently selected from the group consisting of: The compound of Claim 2 wherein X is CR 4R 4, R 4 is hydrogen, R 4 is hydrogen, or a pharmaceutically acceptable salt thereof.ĥ. The compound of Claim 2 wherein R is heteroaryl, wherein said heteroaryl group is optionally substituted with C 1-6 alkyl, or a pharmaceutically acceptable salt thereof.Ĥ. 6 cycloalkyl, C 3.f halo, cyano, Cj^ alkyl, (Cj -6 alkyl)R 7, OR 9, heterocyclyl(R 7), aryl and heteroaryl(R 5) or a pharmaceutically acceptable salt thereof.ģ. 6 alkenyl, (C 2-6 alkeayl)OR 5, (C 2-6 alkenyl)NR 5R 6, C 3. Follow the instructions on page 4 and 5 of the SignTools 4 User Guide.
#VINYL EXPRESS LXI 6.5.3 INSTALL#
R 8 is hydrogen, halo, cyano, hydroxyl, C 1-6 alkyl, (C=0)NR 5R 6 or NR 5R 6 Vinyl Express 24 inch Vinyl Cutter Setup instructions SignTools Settings After installing CorelDRAW the next step is to install SignTools. R 7 is hydrogen, hydroxyl, C 1-6 alkyl, Ci^, haloalkyl, heterocyclyl, OR 9, heteroaryl(OR 9), (C=0)R 5, (C=0)OR 5, (CO)NR 5R 6, (C=0)heterocyclyl, (C=0)N(R 5)heterocyclyl or NR 5R 6 R 6 is hydrogen-or Ci- 6 alkyl, wherein said alkyl is optionally substituted with hydroxyl said alkyl is optionally substituted with hydroxyl or cyano R s is hydrogen or Ci- alkyl, wherein said alkyl is optionally substituted with hydroxyl RR 44' iiss h hydrogen, halo or Ci^ alkyl, wherein. R 4 is hydrogen, halo or Ci^ alkyl, wherein said alkyl is optionally substituted with hydroxyl or cyano
(20) C 1-3 alkyl(C=0)NHR 5 hydrogen, halo or C 1 -3 alkyl Independently selected from the group consisting of (C=0)OR 9, NR 5R 9, NH(C=0)OR 9, NH(C=0)R 9, (C=0)NHR 9, OR 9 and R 9, (15) heteroaryl, which is optionally substituted with one to two substituents said heteroaryl group is optionally substituted with oxo, Cj -6 alkyl, NH(C=0)OR 9 or OR 9 and wherein said phenyl group is optionally-substituted with one to two substituents independently selected from the group-consisting of: R 1 is heteroaryl or aryl, wherein said heteroaryl and aryl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, cyano, C 1-6 alkyl, (Ci-6 alkyl)R 7, OR 9, heterocyclyl(R 7), aryl and heteroaryl(R 5)